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Arnaud FAVIER

Lyon


Biography

I am a CNRS researcher since 2009 in the Lab. Ingénierie des Matériaux Polymères (www.imp.cnrs.fr) in Lyon, France, which is dedicated to fundamental and applicative research on polymer science. My work is mainly devoted to the interface between polymer chemistry and biology, especially to the development of polymer probes for bioimaging applications in infectiology and cancerology (hosted team in the transdisciplinary lab. Joliot-Curie at ENS de Lyon, 2009-2015). Prior to CNRS, I served as scientist in two biotech companies Ilypsa and Relypsa Inc., Santa Clara, California, USA, focusing on polymer therapeutics. I obtained my Ph.D. and M.S. at the University of Lyon, France, in the CNRS/bioMérieux joint unit at ENS de Lyon and completed two post-doctoral research at the University of New South Wales, Sydney, Australia, and the University of Aix-Marseille, France.

Research Topics

My expertise is centered on the synthesis and characterization of taylored polymer architectures for bio-medical applications. Using controlled radical polymerization, especially the RAFT process, I prepare well-defined polymer chains, polymer bioconjugates as well as polymer and hybrid nanoparticles. These biocompatible polymers are designed and evaluated in partnership with biologists to reply to various needs in diagnostic, therapeutic and theranostic applications. In particular for in vitro, in cellulo and in vivo bioimaging, our team develops original fluorescent polymer probes exhibiting many advantages : water-solubility, controlled size and structure, biospecificity, high brightness and adaptable photo-physical properties.

Fields of interest

Well-defined polymer bioconjugates, Bright and biospecific polymer probes for fluorescence microscopy, Polymer-based photosensitizers for photodynamic therapy

Technologies

Optical microscopy techniques, Multiphoton, near-infrared and super-resolution microscopy, Flow cytometry, In vivo bio-imaging, Photodynamic therapy


Applications

Polymer theranostics, Cell biology, Immunology, Cancerology, Infectiology

Everspark

by Eternity

Everspark is a unique dSTORM super-resolution microscopy buffer offering long-term and stable fluorescence imaging over several weeks.

Several publications

Berki T, Bakunts A, Duret D, Fabre L, Ladavière C, Orsi A, Charreyre MT, Raimondi A, van Anken E, Favier A. Advanced Fluorescent Polymer Probes for the Site-Specific Labeling of Proteins in Live Cells Using the HaloTag Technology. ACS Omega. 2019 Jul 30;4(7):12841-12847. https://pubs.acs.org/doi/abs/10.1021/acsomega.9b01643

Duret D, Haftek-Terreau Z, Carretier M, Berki T, Ladavière C, Monier K, Bouvet P, Marvel J, Leverrier Y, Charreyre M. T, Favier A. Labeling of native proteins with fluorescent RAFT polymer probes: application to the detection of a cell surface protein using flow cytometry. Polymer Chemistry 2018, 9 (14), 1857. https://pubs.rsc.org/en/content/articlelanding/2018/py/c7py02064c#!divAbstract

Duret D, Haftek-Terreau Z, Carretier M, Ladaviere C, Charreyre MT, Favier A. Fluorescent RAFT polymers bearing a nitrilotriacetic acid (NTA) ligand at the alpha-chain-end for the site-specific labeling of histidine-tagged proteins. Polymer Chemistry 2017, 8 (10), 1611 https://pubs.rsc.org/en/content/articlelanding/2017/py/c6py02222g#!

 Cepraga C, Marotte S, Ben Daoud E, Favier A, Lanoë PH, Monnereau C, Baldeck P, Andraud C, Marvel J, Charreyre MT, Leverrier Y. Two-Photon Photosensitizer-Polymer Conjugates for Combined Cancer Cell Death Induction and Two-Photon Fluorescence Imaging: Structure/Photodynamic Therapy Efficiency Relationship. Biomacromolecules. 2017 Dec 11;18(12):4022-4033. https://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b01090

Duret D, Grassin A, Henry M, Jacquet T, Thoreau F, Denis-Quanquin S, Coll JL, Boturyn D, Favier A, Charreyre MT. "Polymultivalent" Polymer-Peptide Cluster Conjugates for an Enhanced Targeting of Cells Expressing α(v)β(3) Integrins. Bioconjug Chem. 2017 Sep 20;28(9):2241-2245. https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.7b00362

Lacour W, Adjili S, Blaising J, Favier A, Monier K, Mezhoud S, Ladavière C, Place C, Pécheur EI, Charreyre MT. Far-Red Fluorescent Lipid-Polymer Probes for an Efficient Labeling of Enveloped Viruses. Adv Healthc Mater. 2016 Aug;5(16):2032-44. https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201600091

Adjili S, Favier A, Fargier G, Thomas A, Massin J, Monier K, Favard C, Vanbelle C, Bruneau S, Peyriéras N, Andraud C, Muriaux D, Charreyre MT. Biocompatible photoresistant far-red emitting, fluorescent polymer probes, with near-infrared two-photon absorption, for living cell and zebrafish embryo imaging. Biomaterials. 2015 Apr;46:70-81. 10.1016/j.biomaterials.2014.12.026

Favier A, de Lambert B, Charreyre MT. Toward New Materials Prepared via the RAFT Process: From Drug Delivery to Optoelectronics? In Handbook of RAFT Polymerization, Wiley-VCH Verlag GmbH & Co. KGaA: 2008; pp 483 https://onlinelibrary.wiley.com/doi/book/10.1002/9783527622757

Favier A, Charreyre MT. Experimental requirements for an efficient control of free-radical polymerizations via the reversible addition-fragmentation chain transfer (RAFT) process. Macromolecular Rapid Communications. 2006, 27 (9), 653 https://onlinelibrary.wiley.com/doi/pdf/10.1002/marc.200500839