Odoo • Image et Texte

Charlie GOSSE


« Unleash the force »


After an initial formation at the Chemistry Department of the Ecole Normale Supérieure (Paris), I collaborated with the Physics Department during my PhD, working on the development of magnetic tweezers and on the synthesis of oligonucleotide-made nanostructures. DNA biophysics was still at the heart of my two post-doctoral stays, at Keio University (Yokohama) and Institut Curie (Paris). Then, I entered the Laboratory for Photonics and Nanostructures (Marcoussis), shifting my activities towards microdevice fabrication and analytical sciences. Later, I also devised there several perturbative approaches to study the dynamics of reaction networks, at the molecular as well as at the cellular scale.

Research Topics

Back at the Ecole Normale Supérieure, in its Biology Department, my research still focuses on the kinetics of biomolecules. I am conceiving techniques to measure individual rate constants and exploiting the obtained results to understand more complex reactive systems.

Fields of interest

Thermokinetics characterization of biomolecular interactions; comprehension of reactive network dynamics.


Single-molecule micromanipulation; on chip microreactors; spectroscopy.



by scDNA

Dynatwist is a supercoilable double-stranded DNA molecules with exceptional stability and high purity (> 95%).

Several publications

Kostrz D, Wayment-Steele HK, Wang JL, Follenfant M, Pande VS, Strick TR, Gosse C. A modular DNA scaffold to study protein-protein interactions at single-molecule resolution. Nat Nanotechnol. 2019 Oct;14(10):988-993. https://www.nature.com/articles/s41565-019-0542-7

Mazari E, Zhao X, Migeotte I, Collignon J, Gosse C, Perea-Gomez A. A microdevice to locally electroporate embryos with high efficiency and reduced cell damage. Development. 2014 Jun;141(11):2349-59. https://dev.biologists.org/content/141/11/2349

Hoffmann C, Mazari E, Lallet-Millet S, Le Borgne R, Marchi V, Gosse C, Gueroui Z. Spatiotemporal control of microtubule nucleation and growth triggered by magnetic nanoparticle assembly. Nat. Nanotechnol. 2013 8 199-205. https://www.nature.com/articles/nnano.2012.246

Zrelli K, Barilero T, Cavatore E, Berthoumieux H, Le Saux T, Croquette V, Lemarchand A, Gosse C, Jullien L. Temperature modulation and quadrature detection for selective titration of two-state exchanging reactants. Anal Chem. 2011 Apr 1;83(7):2476-84 https://pubs.acs.org/doi/abs/10.1021/ac1026034

Barilero T, Le Saux T, Gosse C, Jullien L. Fluorescent thermometers for dual-emission-wavelength measurements: molecular engineering and application to thermal imaging in a microsystem. Anal Chem. 2009 Oct 1;81(19):7988-8000. https://pubs.acs.org/doi/abs/10.1021/ac901027f

Estévez-Torres A, Le Saux T, Gosse C, Lemarchand A, Bourdoncle A, Jullien L. Fourier transform to analyse reaction-diffusion dynamics in a microsystem. Lab Chip. 2008 Jul;8(7):1205-9. https://pubs.rsc.org/en/content/articlelanding/2008/lc/b805412f#!divAbstract

Bourdoncle A, Estévez Torres A, Gosse C, Lacroix L, Vekhoff P, Le Saux T, Jullien L, Mergny JL. Quadruplex-based molecular beacons as tunable DNA probes. J Am Chem Soc. 2006 Aug 30;128(34):11094-105. https://pubs.acs.org/doi/abs/10.1021/ja0608040

Koenig A, Hébraud P, Gosse C, Dreyfus R, Baudry J, Bertrand E, Bibette J. Magnetic force probe for nanoscale biomolecules. Phys Rev Lett. 2005 Sep 16;95(12):128301. https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.95.128301

Gosse C, Croquette V. Magnetic tweezers: micromanipulation and force measurement at the molecular level. Biophys J. 2002 Jun;82(6):3314-29. https://www.cell.com/biophysj/fulltext/S0006-3495(02)75672-5