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Gudrun ALDRIAN

Montpellier


Biography 

After having completed my pharmaceutical studies (Graz, Austria), I had the opportunity to realize my PhD in an Austrian-French collaboration (Montpellier, France) dealing with the synthesis and vectorization of PNA (peptide nucleic acids). During my post-doc, I acquired experience on pharmaceutical relevant peptides. In 2001, I joined CNRS, the French center for scientific research, to create a peptide synthesis facility, first at CRBM (Centre de Recherche en Biochimie Macromoléculaire, Montpellier, France) and since 2015 at Sys2Diag, a private-CNRS research structure for the development of medical diagnostics. During all the time, I worked and I am still working on the optimization of peptide vectors in terms of solubility, stability and membrane permeation properties.

Research Topics

As a Pharmacist, almost all my research projects are related to diseases, their understanding and the way to cure them. Peptides are valuable tools to understand protein structures and interactions. They can inhibit or activate protein-protein interactions and they are able to transport and deliver biologically active molecules. During my research work, I had the opportunity to get an insight into a variety of diseases, including cancer, AIDS, diabetes, Alzheimer, Huntington’s and Creutzfeldt Jakob disease and even injuries caused by spider venoms.

Fields of interest

Peptide Chemistry, Biology, Health

Technologies

Peptide synthesis, SPOT synthesis, HPLC, MS


Applications

Peptides as inhibitors/activators, CPP

WRAP

 

WRAP deliver safely nucleic acids in you favorite cells!

Several publications

Bar L., Nguyen C., Galibert M., Santos-Schneider F., Aldrian G., Dejeu J., Lartia R., Coche-Guérante L., Molina F, Boturyn D. (2021) Determination of the Rituximab Binding Site to the CD20 Epitope using SPOT Synthesis and Surface Plasmon Resonance Analyses. Analytical Chemistry doi: 10.1021/acs.analchem.1c00960

Sebastien Deshayes, Karidia Konate, Marion Dussot, Berengere Chavey, Anais Vaissiere, Thi Nhu Ngoc Van, Gudrun Aldrian, Kärt Padari, Margus Pooga, Eric Vives, Prisca Boisguerin (2020) Deciphering the internalization mechanism of WRAP:siRNA nanoparticles BBA - Biomembranes 1862. doi.org/10.1016/j.bbamem.2020.183252

Konate K., Dussot M., Aldrian G., Vaissière A., Viguier V., Ferreiro Neira I., Couillaud F., Vivès E., Boisguerin P., Deshayes S. (2019) Peptide-based nanoparticles to rapidly and efficiently “Wrap’n Roll" siRNA into cells. Bioconjugate Chemistry 30(3):592-603 doi: 10.1021/acs.bioconjchem.8b00776

Aldrian G, Vaissière A, Konate K, Seisel Q, Vivès E, Fernandez F, Viguier V, Genevois C, Couillaud F, Démèné H, Aggad D, Covinhes A, Barrère-Lemaire S, Deshayes S, Boisguerin P. (2017) PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo.J Control Release. Jun 28;256:79-91. doi: 10.1016/j.jconrel.2017.04.012.

Vaissière A, Aldrian G, Konate K, Lindberg MF, Jourdan C, Telmar A, Seisel Q, Fernandez F, Viguier V, Genevois C, Couillaud F, Boisguerin P, Deshayes S. (2017) A retro-inverso cell-penetrating peptide for siRNA delivery. J Nanobiotechnology. Apr 28;15(1):34. doi: 10.1186/s12951-017-0269-2.

Konate K, Lindberg MF, Vaissiere A, Jourdan C, Aldrian G, Margeat E, Deshayes S, Boisguerin P. (2016) Optimisation of vectorisation property: A comparative study for a secondary amphipathic peptide International Journal of Pharmaceutics 509 71-84. doi:10.1016/j.ijpharm.2016.05.030

Huang RK, Baxa U, Aldrian G, Ahmed AB, Wall JS, Mizuno N, Antzutkin O, Steven AC, Kajava AV (2014) Conformational Switching in PolyGln Amyloid Fibrils Resulting from a Single Amino Acid Insertion. Biophys J. 106(10):2134-42. doi: 10.1016/j.bpj.2014.03.047.

Herman B, Aldrian G, Potopalsky A.I, Chroboczek J, and Tcherniuk S.O. (2013) Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation. PLoS One. 8(3):e57461. doi: 10.1371/journal.pone.0057461.

Ranaldi S, Caillava C, Promé S, Rubrecht L, Cobo S, Salvetat N, du Paty E, Galea P, Aldrian G, Le Nguyen D, Krolak-Salmon P, Molina F, Laune D, Checler F, Fareh J, Abraham JD. (2013) N-truncated Aβ peptides in complex fluids unraveled by new specific immunoassays. Neurobiol Aging. 34(2):523-39. doi: 10.1016/j.neurobiolaging.2012.05.016.

Lacroix B, van Dijk J, Gold ND, Guizetti J, Aldrian-Herrada G, Rogowski K, Gerlich DW, Janke C. (2010) Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J Cell Biol. 189(6):945-54. doi: 10.1083/jcb.201001024.